I have treatment-resistant depression. My psychiatrist prescribed a medication that is non-standard after the standard medications failed. My insurance objected, but then agreed to let me try it. However, because the insurance required a new prior authorization every month (causing a 2-week delay in filling the prescription), I was unable to take the medication consistently due to running out of it every month, so I never received enough of the medication for it to have a chance of working. It was a lot of trouble, and I gave up, due to my continuing depression.